He is co-director of the PROductivity From Information Technology (PROFIT) Initiative, and co-Heads the Total Data Quality Management (TDQM) research program.

He has been the Principal Investigator of a large-scale DARPA-funded research effort on Context Interchange which involves the development of technology that helps organizations to work more cooperatively, coordinated, and collaboratively.

He has also been the founder or co-founder of several high-tech firms, including Intercomp (acquired by Logicon), Mitrol (acquired by General Electric's Information Systems Company), Cambridge Institute for Information Systems, founded with John J. Donovan (its successor corporation was named Cambridge Technology Group, founded by John J. Donovan), iAggregate (acquired by ArsDigita, which was subsequently acquired by Red Hat), and now operates a hotel in the 14th-century Langley Castle in Northumberland in northern England.

[2] Madnick is involved with the research effort at BMLL Technologies,[6] a Cambridge spin-off working in the field of machine learning application in the financial sector.

Madnick is the author or co-author of over 250 books, articles, or reports including the textbook, Operating Systems (McGraw-Hill), and The Dynamics of Software Development (Prentice-Hall).