The song spent three weeks at number one on the US Billboard Hot 100, becoming the band's second number-one hit on the chart.

Internationally, the song became the band's second top-20 hit in the United Kingdom, reaching number 12 on the UK Singles Chart, and peaked within the top 10 in Australia, Canada, Iceland, South Africa, and New Zealand.

"[4] Billboard said it has "a skewed love lyric set to street-corner harmonizing.

"[5] The music video for "Stuck with You" was filmed in the Bahamas in July 1986 and features Keely Shaye Smith.

The video was directed by Edd Griles, who had previously directed the band's videos for "The Heart of Rock & Roll" and "If This Is It", as well as Cyndi Lauper's "Girls Just Want to Have Fun" and "Time After Time".