Cody Anthony Miller (Jamie Elman), the protagonist of the show, was the cartoonist for the high school newspaper publication of the same name as the show, which rivaled the official school paper led by Victor Kane (Miklos Perlus).

Another main source of Cody's cartoon drawings were his relationships with his girlfriends throughout the series, who included "Student Bodies" editor Emily Roberts (Nicole Lyn) and fellow member Grace Vasquez (Victoria Sanchez), and other characters including "transition" girlfriend Holly Benson (Katheryn Winnick) and Kim McCloud (Jennifer Finnigan), who became a main character in the third season.

Others in the cast included Erin Simms, who played Morgan McKnight in the first season and was the object of Chris Sheppard's (Ross Hull) infatuation, before he and Margaret "Mags" Abernathy (Katie Emme McIninch) became a couple on the show.

Jessica Goldapple played Francesca "Flash" Albright, the photographer loyal to Victor Kane (Miklos Perlus) and Mark Taylor played Romeo Carter, who became Emily's boyfriend after Cody and Emily broke up.

Staff at Edison High included vice-principal Mrs. Morton, played by Michelle Sweeney.