The river formed the trajectory for the Spanish conquest of the Muisca, when the conquistadors went uphill into the Andes from the tropical lowlands of Barrancabermeja in the north.

[7] Nearby Lake Suesca has an endorheic basin, not flowing out to the Suárez River.

[3] In Saboyá, various flora surrounding the Suárez River have been registered, among others Inga sp., Croton funckianus, Mircyanthes sp., Gynerium saggitattum, tropical smoke bush (Euphorbia cotinifolia), castorbeans (Ricinus communis), Alchornea sp., Colombian oaks (Quercus humboldtii), Eucalyptus globulus and Cupressus sp., Pinus sp.

[10] The Suárez River is of importance in the history of Colombia, as it formed the fluvial artery that the conquistadors followed after they left the tropical lowlands of La Tora, present-day Barrancabermeja, uphill towards the Muisca Confederation.

The Spanish conquerors followed the course of the Suárez river on the left bank until reaching Lake Fúquene.