Subbaraju has played a variety of roles, from negative to supporting characters.

[2] Subbaraju was born in Bhimavaram, to Penmatsa Ramakrishnam Raju and Vijayalakshmi.

His most notable works include Amma Nanna O' Tamil Ammayi, Arya, Pokiri, Leader, Bbuddah... Hoga Terra Baap, Businessman, Mirchi, Baahubali 2: The Conclusion, Temper, Duvvada Jagannadham, Geetha Govindam, and Majili.

Subbaraju is immensely popular in Japan for his role as Kumara Varma in the 2017 epic action film, Baahubali: The Conclusion.

On 26th November 2024, Subbaraju shared via Instagram that he had tied the knot to Dr. Sravanthi Tapal in Florida, United States.