As an Istiqlal leader, he helped organize anti-British and anti-Zionist activities in Palestine, including the 1936–39 Arab revolt, which resulted in his three-year imprisonment.

After interrogation and debriefing in Cairo, where he provided several articles to the magazine Al-Kawkab, he joined Sharif Hussein bin Ali's forces in the Arab Revolt against the Ottomans.

[3] He participated, as representative of Safed, in the Emergency Relief Committee, an organization headquartered in Jerusalem that sought to provide aid to afflicted Palestinian families.

[4] As an attorney and a director of the Waqf (Islamic trust fund) in the Galilee, he helped establish the Young Men's Muslim Associations (YMMA) in the area.

[5] He wrote an article in 1930 that claimed Zionism was an "imperial British tool" and part of its divide-and-conquer method in the Arab world; he launched the slogan "The English are the origin of the malaise and at the head of every calamity".

He explained in an article in al-'Arab that the party's purpose was to counter factionalism and self-interest in Palestinian politics which had left the liberation movement without direction.

[9] Al-Khadra greatly assisted Arab guerrilla leader Sheikh Izz ad-Din al-Qassam with forming paramilitary units and increasing membership in his anti-Zionist movement.