The term is derived from sub- meaning "under" in Latin and masseteric which refers to the masseter muscle.

[1] Sometimes mandibular fractures in the region of the angle of the mandible may cause an infection of the submasseteric space.

[1] The signs and symptoms of a submasseteric abscess may include marked trismus (i.e. difficulty opening the mouth, since the masseter elevates the mandible and it becomes restricted) and swelling in the region of the masseter muscle.

[1] The treatment of a submasseteric space infection is usually by surgical incision and drainage, and the incision is placed intra-orally (inside the mouth) or both intra and extra-orally if other parts of the masticator space are involved.

The submasseteric space is sometimes involved by the spread of odontogenic infections, such as a pericoronal abscess associated with an impacted mandibular third molar (lower wisdom tooth) when the apices of the tooth lie very close to or within the space.