[3] The territory of the region is virtually co-extensive with the territory of the pre-colonial kingdom of Sanwi, which as late as 1969 attempted to break away from Ivory Coast and form an independent state.

Since 2002, the King of Sanwi has been Nana Amon Ndoufou V. Sud-Comoé Region was established in 1997 as a first-level administrative region.

As part of the 2011 administrative reorganisation of the subdivisions of Ivory Coast, Sud-Comoé was converted into a second-level division with no territorial changes.

It was combined with Indénié-Djuablin to form the new first-level Comoé District.

[4] Sud-Comoé Region is currently divided into four departments: Aboisso, Adiaké, Grand-Bassam, and Tiapoum.