Prior to becoming Governor, Soediro served as Jakarta's mayor for five years until the city was made its own special capital region.

He was also active in education, becoming the head of a Meer Uitgebreid Lager Onderwijs (Junior High School) between 1931 and 1933, and later he chaired Taman Siswa in Madiun between 1933 and 1936.

[1][2] During the Japanese occupation of the Dutch East Indies, Soediro became one of the leaders of the Barisan Pelopor, a militant arm of the Japan-formed Jawa Hokokai.

His plan was to steal a Buick limousine belonging to the Japanese Chief of Railways, which he believed to be the best car in Jakarta.

Shortly after his appointment, in January 1954 he reorganized the city's local electoral committees, which resulted in large protests.

[11] His administration saw the preparation for the construction of the Istiqlal Mosque and Hotel Indonesia, and despite little success, Soediro fought for the conservation of both Jakarta's electric tram and historical sites.