[1] Myerscough served as a law clerk for Judge Harold Baker of the United States District Court for the Central District of Illinois and was in private practice in Springfield, Illinois from 1981 until her appointment as associate judge in 1987.

[2] On October 11, 1995, President Clinton nominated Myerscough to a seat on the United States District Court for the Central District of Illinois that was vacated by Judge Harold Baker, who assumed senior status in 1994.

In February 2010, Senator Dick Durbin recommended Myerscough to President Obama for a seat on the district court.

Myerscough was nominated to fill the vacancy created by Judge Joe Billy McDade, who assumed senior status on February 28, 2010.

[4][1] On July 14, 2010, Obama withdrew Myerscough's name to fill the McDade vacancy and instead renominated Myerscough to fill the vacancy being created by Judge Jeanne E. Scott, who retired on August 1, 2010.