After being brought to the throne by an armed mutiny, Suleiman and his grand vizier Fazıl Mustafa Pasha were successfully able to turn the tide of the War of the Holy League, reconquering Belgrade in 1690, as well as carrying out significant fiscal and military reforms.

In 1688, Suleiman II urgently requested the Mughal Emperor Aurangzeb for assistance against the rapidly advancing Austrians, during the Ottoman–Habsburg War, but most Mughal forces were engaged in the Deccan Wars and Aurangzeb ignored Suleiman's request to commit to any formal assistance to their desperate Ottoman allies.

[7] Suleiman II appointed Köprülü Fazıl Mustafa Pasha as his Grand Vizier in 1689, leading to the reconquest of Belgrade in 1690.

It is not known whether this was due to his sterility, lack of sexual interest, or his precarious health conditions, which forced him to be bedridden for the final half of his short reign.

He died on 22 June 1691 and his body was buried in Suleiman the Magnificent's tomb at Süleymaniye Mosque in Istanbul.