[1] Macau is a fusion of Chinese and Western culture that stretches back to the 16th century when it was opened up as a harbour for trade with the West.

Both Cuiheng and Macau were historically under the sway of Xiangshan County before gradually succumbing to the occupation of the Portuguese in the second half of 19th century.

From whence he accompanied his mother on his first sea voyage on board the British iron ship S.S. Grannock bound for Honolulu in Hawaii to embark upon a western education.

In 1892, Dr. Sun was invited by Kiang Wu Hospital in Macau to set up the Western Medicine Department as a voluntary doctor and diagnosed patients for free.

With borrowed funds from the hospital, he subsequently opened the Chinese-Western Medicine Joint Clinic in Rua das Estalagens and was well known for his outstanding medical skills and enjoyed widespread admiration in the community.

[4] During this period, Sun Yat-Sen made many revolutionary statements and his first great essay—Letter to Zheng Zaoru—in his anthology was published by a Macau newspaper in 1890.

During the Chinese Revolutionary Party years straddling 1915, Sun Yat-Sen and his associates regarded Macau as an important base for their defensive activities in Southern China.

Later, two of his earlier essays were incorporated in Zheng's Sheng Shi Wei Yan ("Warnings to a Prosperous Age"), a collection of his works that act as a welcome boost to Dr. Sun fledgling revolutionary aspirations.

As a Macanese, Fernandes accepted democratic ideology prevalent in Western countries at that time, and thus he was sympathetic towards, and supported Dr. Sun's revolutionary cause.

Over 20,000 people (one fifth of the city's population then) in Macau attended the solemn memorial ceremony held at Kiang Wu Hospital on 29 March 1925.

The House is currently open to the public which showcases his books, letters, photographs, personal belongings and old newspapers accounts of his life and the Chinese republican revolution which finally overthrew the regime of the Qing Dynasty in 1911.