A reference of Kara Zor-El is seen in Man of Steel where Clark sees an empty space pod open in the Fortress of Solitude.

The original ending had Kara surviving to the new timeline, which was changed following the merger of WB and Discovery, as well as James Gunn and Peter Safran taking over and rebooting the franchise.

Gunn described the project as "a big science fiction epic film" and said it would explore a more "hardcore" version of Supergirl than had been previously seen on screen.

Kara is greatly reluctant to face Brainiac again, even with super powers, but eventually summons the courage to help her cousin fight him.

Supergirl appears in Lego DC Comics Super Heroes: Justice League: Cosmic Clash, voiced by Jessica DiCicco.

[18] Kara Zor-El / Supergirl appears in Justice League: Crisis on Infinite Earths – Part One, a 2024 film set in the Tomorrowverse continuity, voiced again by Meg Donnelly.

Kara and her family were placed in suspended animation to survive the planet's gradually decreasing temperatures, but the stasis chambers failed over time, leaving her as the only survivor.

Superman discovers Kara while searching for life in Krypton's solar system and brings her to Earth, where she is adopted by Jonathan and Martha Kent.

Living in the peaceful Kansas countryside and reveling in her powers in the planet's yellow sun environment, Kara soon recovers from any grief and shock over her loss of her family upon revival and takes on the Supergirl moniker.

[20][21] Supergirl shares Superman's vulnerability to kryptonite (except in the comic book adaptation of the series[22]); she also suffers from cheimatophobia (fear of cold), due to her experiences prior to her time in suspended animation.

In a departure from her traditional outfit, Supergirl has a white shirt, blue skirt and a red cape in Superman: The Animated Series.

In the third season of JLU, Supergirl appears in a new outfit, the more traditional blue shirt with red miniskirt that resembles Kara Zor-El's post-Crisis costume.

As Kara experiences the technology and society of the future, which is similar to that of her lost homeworld, she becomes conflicted about returning to the past, where she has never felt that she fits in.

[24] Supergirl appears alongside Batgirl and Wonder Girl in Super Best Friends Forever, a series of shorts developed by Lauren Faust for the DC Nation block on Cartoon Network.

[25] Supergirl appears as a central protagonist in the web series DC Super Hero Girls, voiced by Anais Fairweather.

She also appears a central protagonist in the 2019 TV series, with Nicole Sullivan reprising her role from the Super Best Friends Forever shorts.

She was revealed at episode's end to be Lindsey Harrison, a human empowered and controlled by Kryptonian technology as part of Jor-El's plan to influence Clark.

The Martian Manhunter AKA John Jones is similarly distrustful of her, as Kara is of him, claiming that Zor-El attempted to have Jor-El assassinated.

In the episode "Traveler", Kara's memory and powers are restored by Jor-El making her able to save Clark, who was imprisoned in a Kryptonite cell.

In the following episode, entitled "Veritas", Kara attempts to teach Clark how to fly so as to further his chances of surviving a confrontation with the newly restored Brainiac.

Kara was found and raised by Lex and Lionel Luthor, and took on the name Linda Danvers, being head of DDS (Department of Domestic Security).

The season finale "Arctic" reveals that the real Kara never made it back to Earth and is trapped in the Phantom Zone, and that Brainiac had been impersonating her.

Kara spends her remaining teenage years with the Danvers family at Superman's suggestion, deciding to live a normal life while she and her adopted sister Alex move to National City.

However, Kara was forced to reveal herself to save an crashing airplane and was later recruited by the Department of Extra-Normal Operations, a secret agency Alex works for.

[34] When the Arrowverse Earth-1 is attacked by the alien Dominators, Barry Allen recruits Kara to help him and his Earth's heroes in opposing the invasion.

After the battle concludes, Kara is given a device by Cisco Ramon that will allow her to travel back and forth to Earth-1, as well as call the other heroes for assistance if required.

But Kara manages to escape being operated and participated in the final battle with Earth-1's heroes and Earth-Xs' forces, taking Overgirl into the upper atmosphere as she was about to detonate in a nuclear-level explosion.

Supergirl first appeared in the PSP version of Justice League Heroes as an unlockable character, voiced by Tara Strong.

Supergirl appears as a playable character in Lego Batman 2: DC Super Heroes, voiced by Bridget Hoffman.

In Larry Niven's essay "Man of Steel, Woman of Kleenex", he speculated on Supergirl being used as the surrogate mother for a child of Superman and Lois Lane to preserve the Kryptonian race.