It is notable as the birthplace of suffragist Susan B. Anthony in 1820 and for its association with early educators and industrialists in Adams.

Daniel Anthony's store, which Susan's father ran out of the northeast room of the family home to supply the needs of his textile workers and neighbors, has been recreated the way it may have been in 1817.

David was a strong proponent of education, teaching at the East Road School, and joining with others in the tightly knit Quaker community to found the Adams Academy in 1825 on land owned by his father.

[4] One of the exhibits is about Restellism, a name for abortion that was first heard in a popular lecture, portions of which were reprinted on March 4, 1869, by editors Elizabeth Cady Stanton and Parker Pillsbury in the pages of Anthony's newspaper The Revolution.

It shows 122 references taken from Anthony's newspaper—mentions of Restellism which offer insight into how the women's rights activists came to oppose this practice.

The museum's initial mission statement included "raising public awareness" of Anthony's "wide-ranging legacy" including her being "a pioneering feminist and suffragist as well as a noteworthy figure in the abolitionist, opposition to restellism and temperance movements of the 19th century"[7] (emphasis added.)

A local paper reported that the exhibit about Restellism implies that the rejection of advertisements shows Anthony's personal views about abortion.

[6] Answering this assertion, Crossed said, "the pro-life views expressed in Anthony's newspaper, The Revolution, will not be excluded from the exhibition.