Access to the house is through the Susan B. Anthony Museum entrance at 19 Madison Street.

Today the Susan B. Anthony House is a learning center and museum open to the public for tours and programs from 11-5 Tuesday through Sunday, except major holidays.

The house hosts an annual celebration of Nineteenth Amendment to the United States Constitution, which gave women the right to vote.

[6][7] In 2011, the New York Times reported that the museum at the house had sold a large quantity of "a $250 handbag made of fake alligator that was inspired by one of Anthony’s own club bags, similar to a doctor’s bag," noting that for Anthony, "a bag was not a fashion statement but a symbol of independence at a time when women were not allowed to enter into a contract or even open a bank account.

[9] The House's president wrote to "decline" President Donald Trump's August 2020 pardon to Anthony, on the principle that to accept a pardon would wrongly "validate" the trial proceedings in the same manner that paying the $100 fine would have.