[7] Prior to entering politics, Holt worked as a human resource manager in Fredericton,[5] where she served as chief growth officer for software testing companies PLATO Testing and PQA,[8] and served as president of the New Brunswick Business Council.

[13] In November 2022, Holt announced that she would accept his offer and run in Landry's riding of Bathurst East-Nepisiguit-Saint-Isidore.

[14] On April 24, 2023, Holt won a by-election in Bathurst East-Nepisiguit-Saint-Isidore to win a seat in the Legislative Assembly.

[15] The Liberals won 31 seats in the 2024 general election, making Holt the premier-designate to succeed Blaine Higgs of the Progressive Conservative Party.

On November 7, 2024, Holt and her government approved changes to Regulation 84-20, repealing a 1984 rule which restricted Medicare funding for surgical abortions performed outside of hospitals.