After college, she worked as a senior editor at Seventeen magazine and also as a freelance political speechwriter.

[4] It was chosen as a main selection of the Book of the Month Club and was a New York Times bestseller.

She has also written a work of cultural criticism, Brave Dames and Wimpettes: What Women are Really Doing on Page and Screen, and a novella, A Hint of Strangeness.

In 1985, Isaacs adapted her own novel for the screenplay of the Paramount film Compromising Positions, which starred Susan Sarandon and Raul Julia.

She wrote and co-produced Touchstone Pictures' Hello Again, a 1987 comedy starring Shelley Long, Gabriel Byrne, and Judith Ivey.

She belongs to the Creative Coalition, PEN, the International Association of Crime Writers, the American Society of Journalists and Authors.