Prior to entering the House of Commons, she pursued a career in infrastructure finance and in 2000 was a candidate in the London mayoral election.

[2] Kramer contested Dulwich and West Norwood in 1997, coming third behind the Labour incumbent Tessa Jowell and the Conservative candidate Roger W. Gough.

In March 2003, she again sought the party's nomination for Mayor of London, but was beaten in a three-way race for the candidacy by Simon Hughes.

[citation needed] In September 2003, Kramer was selected as the prospective parliamentary candidate for the constituency of Richmond Park in South West London, following the decision of the sitting Liberal Democrat MP, Jenny Tonge, to stand down at the next election.

Kramer was appointed as the Liberal Democrat spokesperson on International Development by the new party leader, Sir Menzies Campbell, in March 2006.

When Nick Clegg was appointed as Liberal Democrat Leader, Kramer received a demotion to a spokesperson for the Cabinet Office.

In January 2009, she resigned from the party's front bench to defend her seat from a renewed Conservative campaign to regain Richmond.

A Liberal Democrat spokeswoman said to the press Jonathan Kramer was unaware his name had fallen off the register, and that the money was paid back once the error was pointed out.

She has voted against the introduction of national ID cards, against the renewal of the Trident defence system, and for an elected House of Lords.

[9] On civil rights, Kramer voted for amendments to the Equality Act 2006 that would ban discrimination based on sexual orientation and gender reassignment.

[10] In early January 2009, Kramer stepped down from the Liberal Democrat Front Bench to focus on local issues impacting her constituency.