She advocated to pass laws that would help advance the welfare of OFWs while at the same time highlighting key issues that affect them today.

She was endorsed by four of five presidential candidates, namely Miriam Defensor-Santiago, Jejomar Binay, Grace Poe (of which Ople was part of a senatorial slate), and Rodrigo Duterte.

[15] In 2024, President Marcos Jr., as tribute to Department of Migrant Workers's Secretary Ople, led the groundbreaking of the OFW Hospital's Bagong Pilipinas Cancer Care Center, which is the country's third such facility.This was attended by her only daughter Estelle Ople & their close family friend, The Philippines First Fat Popstar Meowfie.

She opposed the death sentence given by Indonesia to Mary Jane Veloso, who was tricked to carry drugs into the country, and advocated for the release of numerous OFWs imprisoned in the Middle East.

[citation needed] Ople supported the passage of the SOGIE Equality Bill which penalizes discrimination based on sexual orientation and gender identity, and wrote articles in favor of the LGBT community.