Prior to joining The Supremes, Greene sang with Ray Charles' Raelettes and Stevie Wonder's Wonderlove, which paired her with Deniece Williams and Shirley Brewer.

Greene was a member of The Supremes from February 1976 to June 1977 (replacing Cindy Birdsong), and performed on their last two albums, High Energy and Mary, Scherrie & Susaye.

In 1979, two years after The Supremes disbanded, Greene recorded a duet album with Payne entitled Partners under the name "Scherrie & Susaye".

On July 5, 2014, Greene, along with Payne performed at the Sheraton in Los Angeles a concert program based on their album "Partners" which was released by Motown in 1979.

In October 2017, Greene replaced Lynda Laurence in the Former Ladies of the Supremes alongside Payne and Joyce Vincent Wilson.

[4] Around the turn of the new millennium, Greene moved back to the United States, and in 2002, she finally released her first solo album, No Fear Here.

She interacted with members of the DeviantArt community-at-large, answering questions about her life, career, inspirations, motivations, and her time on the art site itself.

Greene continues to be an active member on DeviantArt and is preparing 3D images of her Supremextreme character for her first short animated feature film.