Guided by a desire to provide a forum that would be innovative, relevant, and engaging, they worked alongside community and business leaders with volunteers to create the museum.

Today, SAM is Central Pennsylvania's only dedicated art museum, mounting exhibitions that reflect the diverse cultural heritage of the community as well as a wide range of aesthetic interests.

Educational programming is developed to enhance and enrich the visitor experience, providing a wide variety of classes, lectures, workshops, discussions, critiques, and more for adult learners.

[2] On January 16, 2015, the Susquehanna Art Museum relocated to the transformed former Keystone Trust Building, located at 1401 North Third Street, Harrisburg, PA 17102.

The structure was originally constructed as a bank in 1913, later converted to a department store, and now serves as a dormitory building for Harrisburg University students, with a Subway restaurant on the first floor.