The twelve teams play home and away matches from September through to April.

The creation of National 5 South meant that Sussex 2 dropped from a tier 9 league to a tier 10 league for the years that National 5 South was active.

The cancellation of National 5 South at the end of the 1995–96 season meant that Sussex 2 reverted to being a tier 9 league.

Additionally, both regional divisions dropped to tier 10 leagues due to the introduction of London 4 South East.

Sussex 2 was re-merged back into a single division ahead of the 2002–03 season, remaining at tier 10 of the league system.