In 2005 the marketing name was again changed when Suzuki replaced the carburetors with fuel injection, with M standing for 'muscle' and 50 representing the displacement of the engine in cubic inches.

Intruder M800 refers to the 800 cubic centimetre engine following the naming convention for Suzuki cruisers in markets outside North America.

The M50 received different fenders and fuel tank from the C50, a handlebar mounted speedometer cluster, and inverted 41mm forks, to give it a more muscular appearance than the C50 semi-sister.

[1] The M50 featured distinctive styling, with a unique rear fender, LED taillight, black painted mag wheels, and aggressive stance.

Sales numbers for the redesigned M50 are unavailable, as Suzuki chose not to ship any 2010 models to North America due to the large supply of leftover 2009s in dealer inventory.