Initially intended as a one-time CD launch benefit for Victoria Williams, Sweet Relief has evolved into a charity organization that relies on donations from artists and the public as a general fund to all professional musicians in need.

The fund provides financial assistance to all types of career musicians who are struggling with their finances while facing illness, disability, or age-related problems.

The organization was started after musician and singer Victoria Williams was diagnosed with multiple sclerosis (MS) in 1993 and had no way to pay for her medical expenses.

A second CD titled Sweet Relief II: Gravity of the Situation was released in 1996.

Some well-known artists including Garbage, R.E.M., Hootie and the Blowfish, The Smashing Pumpkins, Joe Henry and Madonna performed for the CD.