The men's 400 metre individual medley event at the 2010 Asian Games took place on 13 November 2010 at Guangzhou Aoti Aquatics Centre.

There were 15 competitors from 11 countries who took part in this event.

The heat in which a swimmer competed did not formally matter for advancement, as the swimmers with the top eight times from both field qualified for the finals.

Asian record holder Yuya Horihata from Japan won the gold medal with 4 minutes 13.35 seconds.

All times are China Standard Time (UTC+08:00) Prior to this competition, the existing world, Asian and Games records were as follows.