Swimming at the 2010 Central American and Caribbean Games was taking place July 18–23 (Days 2–7) at the RUM Natatorium in Mayagüez, Puerto Rico.

[1] The swimming competition featured a prelim/final format, with Prelims beginning at 9:00 a.m. and Finals at 6:00 p.m. Finals event schedule is:[2] 207 total swimmers from 24 countries participated at the 2010 Games.

[3] Team delegates (with size) were from: *   Host nation (Puerto Rico)