The women's 50m backstroke S4 event at the 2012 Summer Paralympics took place at the London Aquatics Centre on 6 September.

There were two heats; the swimmers with the eight fastest times advanced to the final.

Lisette Teunissen won gold representing the Netherlands.

EU = European Record.

Official London 2012 Paralympics Results: Heats Archived 2012-09-13 at the Wayback Machine Official London 2012 Paralympics Results: Final Archived 2012-09-13 at the Wayback Machine