The women's 100 metre freestyle competition at the 2022 Mediterranean Games was held on 3 July 2022 at the Aquatic Center of the Olympic Complex in Bir El Djir.

[1] Prior to this competition, the existing world and Mediterranean Games records were as follows: The following records were established during the competition: The heats were started at 11:14.

[2] The final was held at 18:31.

[3]