It had its legal headquarters[6] in Basel; the physical head office was on the grounds of Zürich Airport and the town of Kloten.

[3] On 11 March 2009, the Lufthansa Group board announced that it planned to gradually replace the current Avro RJ100 fleet flown by Swiss Global with aircraft of the Bombardier CSeries from 2014.

[10] The replacement of the twenty RJ100s was planned to take two years, while an additional ten aircraft would be delivered thereafter to allow for capacity expansion.

[17] By April 2015, Swiss Global Air Lines requested traffic rights for flights to the United States to utilize the 777s on its parent's intercontinental routes.

On 14 August 2017, the final revenue RJ100 flight occurred, with the aircraft's formal retirement from Swiss service the following day.

The reason for this is considered to be the new labour agreement harmonizing pilot compensation across both companies that took effect on 1 April, negating the cost advantages of Swiss Global Airlines.