Syamzha (Russian: Ся́мжа) is a rural locality (a selo) and the administrative center of Syamzhensky District of Vologda Oblast, Russia, located on both banks of the Syamzhena River, a tributary of the Kubena River.

[8][9] On July 15, 1929, Syamzhensky District with the center in the village of Yarygino was established and became a part of Vologda Okrug of Northern Krai.

In the same year, the selo of Syamzha was established by merging several villages at the crossing of the Syamzhena River by the highway connecting Vologda and Arkhangelsk.

[11] The economy of Syamzha is dominated by timber industry, which produces 82% of all goods in the district.

[8] One of the principal highways in Russia, M8, which connects Moscow and Arkhangelsk, crosses Syamzhensky district from the south to the north, passing through Syamzha.