The Chicago and Northwestern Depot is a historic railway station located at the northeast corner of Sacramento and DeKalb Streets in Sycamore, Illinois.

The original line, which opened in 1855, lacked an engine and pulled railcars by mule; as the railway became more successful, it was able to purchase an engine and build the station in Sycamore.

The station has an Italianate design which resembles contemporary DeKalb architecture but is noticeably different from the standardized depots built elsewhere in the C&NW system.

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