He is best known for Mystery Theater, Badtameez, Tum Se Kehna tha, Shaista Shaista, Azar Ki Ayegi Baraat, Annie Ki Ayegi Baraat, Tanhaiyan Naye Silsilay, Dareecha, Goya, and many other series and telefilms such as Khamoshi, Ghoongat and Ramchand Pakistani.

In 2019, he received a nomination for Best Actor for his role in the 2018 film Cake, at the 18th Lux Style Awards.

Desi Rants n Raves wrote "Mohammed Ahmed is a seasoned writer and his flair for penning relatable and real stories is on full display in most of his work.

With no black or white extremes, a simple story on the surface, his script appears to have layers of meaning embedded within crisp and meaningful dialogues.

[7] He has also acted in various drama series including Ehd E Wafa, Suno Chanda, Mere Paas Tum Ho, Aulaad and Sabaat.