The premiere took place on 12 June 1778 in a private performance in the home of Count Karl Heinrich Joseph von Sickingen, the ambassador of the Electorate of the Palatinate.
[2] The work received a positive review in the June 26 issue of the Courrier de l'Europe, published in London: The Concert Spirituel on Corpus Christi Day began with a symphony by M. Mozart.
[a] [3]The work was performed again at the Concert Spirituel on 15 August, this time with a new second movement, an Andante replacing the original Andantino in 6/8 (the latter, according to Deutsch, "had failed to please".
[6] The symphony was later performed in the Burgtheater in Vienna on 11 March 1783 during a benefit concert for Mozart's sister-in-law, the singer Aloysia Weber.
The number of string players is (as usual) not specified in the score, but Sadie remarks that at the premiere there were 22 violins, five violas, eight cellos, and five basses.