The song was written by German composer team Irmgard Klarmann and Felix Weber.

The theme of the song focuses on Spencer discovering that she is suffering from "symptoms of true love" and lists the causes.

"Symptoms of True Love" was Spencer's first single to chart on the Billboard Hot 100, reaching number 38.

The music video for "Symptoms of True Love" is rather simple and it was made in March 1988, and it shows Spencer and a group of friends dancing and grooving along to the song.

The video's set features comic book-style art in the vein of Roy Lichtenstein.