In the final of the Pertemps series at the Cheltenham Festival a month later he started at odds of 9/1 in a field of twenty-two runners but seemed to be well beaten when falling at the last obstacle.

After starting the season with two runs over hurdles, he again showed his aptitude for extreme stamina tests as he carried 160 pounds to victory over 3 miles, 5+1⁄2 furlongs in the Welsh National in January.

[9] He once again bypassed the Cheltenham Festival, but his attempt to win a second Midlands National ended in failure as he finished third to Minella Four Star under top weight of 166 pounds.

The 2011/2012 season began with two more hurdle races before Synchronised was moved up to Grade I class for the first time in the Lexus Chase at Leopardstown Racecourse in December.

The gelding established himself as a top-class steeplechaser by taking the lead at the last fence and pulling clear in the closing stages to beat Rubi Light in "impressive style"[10] by 8+1⁄2 lengths at level weights.

McCoy praised his horse's performance but was not over-enthusiastic about his prospects against the best steeplechasers saying "I don't think Kauto Star and Long Run will be too worried".

[12] The betting for the 2012 Cheltenham Gold Cup was dominated by the former winners Long Run and Kauto Star, but Synchronised was also quietly fancied and started the 8/1 joint-third favourite with Weird Al in a field of fourteen runners.

Synchronised was still only sixth as the field approached the straight, but his stamina proved decisive as he stayed on strongly to dispute the lead at the last fence before pulling away to win by two and a quarter lengths from the 50/1 outsider The Giant Bolster.

He continued running riderless until attempting to jump the 11th fence where he incurred a fracture of the tibia and fibula in his right-hind leg and racecourse vets had to euthanise him.