[5] The species is native to a wide region of Latin America from Mexico through Bolivia, and naturalized in the West Indies, Florida, Texas, Hawaii, and other places.

It was originally confused with the similar-looking African genus Nephthytis, and this is still used as a common name for the plant.

[16] It climbs a few meters tall over the trunks of tropical jungle trees, clinging by its roots.

There are several variegated cultivars, the main differences being in the position and extent of the cream or white markings.

[citation needed] To ensure adequate humidity, the plant pot should be placed in a larger container with constantly moist peat and sprayed with water daily.

[20] All parts of Syngonium podophyllum are poisonous and cause severe mouth pain if eaten.

[21] It is not unusual to find these growing in Sub-tropical Florida landscapes, where homeowners and Gardeners need to be aware of the severe skin burning sensations caused by the plants sap containing oxalic acid and the eye damage potential from raphides.