In 2009, Synygy began using third-party products to deliver its services, and the company exited the software development business.

Synygy's first three clients were the pharmaceutical companies Schering-Plough, Janssen Pharmaceutica, and Wyeth-Ayerst.

[8] During its 25 years in business, Synygy served nearly all industries, including Life Sciences, Manufacturing and Distribution, Retail, Banking, Financial services, Telecommunications, High-Tech, and Insurance (Health, Life, Property & Casualty).

[citation needed] Synygy competed with professional services companies that include Accenture, CallidusCloud, Alexander Group, Aon Hewitt, Bain & Company, Better Sales Comp, Boston Consulting Group, Buck, Canidium, Colletti-Fiss, Cygnal Group, Deloitte, KPMG, McKinsey & Company, Mercer, OpenSymmetry, Sibson, Towers Watson, Valitus, and ZS Associates.

[13] Starting in 2005, Synygy's US headquarters was situated in a Beaux Arts-style building (c. 1918) along the Delaware River.