Syracuse is a city in Morgan County, Missouri, United States.

[3] In the middle of the 19th century, the city was the western terminus of the Pacific Railway that reached 108 miles from St.

In 1859 with the railroad construction to Syracuse, it became the Terminus of The Butterfield Overland Mail Route.

Versailles, the Morgan county seat, is 19 miles (31 km) to the south via secondary highways.

According to the U.S. Census Bureau, Syracuse has a total area of 0.38 square miles (0.98 km2), all land.

22.1% of all households were made up of individuals, and 14.7% had someone living alone who was 65 years of age or older.

None of the families and 4.5% of the population were living below the poverty line, including no under eighteens and 18.2% of those over 64.

Syracuse is home to the KMOS TV Tower, built in 2003 and operated by the University of Central Missouri.