Its seat is Saint Mary Church of the Holy Belt Cathedral in Homs, Syria.

The Syriac Orthodox Diocese of Homs, also known as Emesa, has a rich history dating back to the early centuries of Christianity.

While specific details about its exact founding are limited, it is believed to have existed as a significant center of Syriac Christianity for centuries.

Many Syriac Orthodox Christians were forced to flee their homes, and the diocese suffered significant losses.

Mainly the cities of Homs and Hama (recently Tartous) with the villages around, Zaidal, Fairouzeh, Sadad, Al-Hafar, Maskanah, Al-Qaryatayn and Fhaylah.