[12] The group portrayed its threats to attack HTS and HTS-affiliated leaders as part of its response against the claimed extrajudicial killings of Christians, Shias, and Alawites after the fall of the Assad regime.

[26] On 25 January, members of the Syrian Popular Resistance assassinated a local leader of Hay'at Tahrir al-Sham, Ahmed al-Wazir Abu Akar, and wounding other men that were with him at the time of his death in the vicinity of the Dabousieh area in the Talkalakh District of Homs Governorate, and on the same day, Syrian Popular Resistance militants executed an ambush targeting a military vehicle belonging to Hay'at Tahrir al-Sham which resulted in several deaths and injuries of Hay'at Tahrir al-Sham militants, including a higher ranking militant by the name of Muhammad Abdul Qadir Khalil, also known by the nom-de-guerre Abu Abdo Talbiseh.

[28] They officially claimed responsibility on 1 February 2025 in a statement released on their Telegram channel, stating more attacks will continue,[29] The IDF acknowledged the incident, but said that they had suffered no injuries.

[31] On 1 February, the Syrian Popular Resistance claimed responsibility for an ambush on the Latakia-Aleppo highway near Al-Mukhtariyah in Latakia countryside, in which one member of Military Operations Command was killed, two others were injured and a fourth one went missing.

[35][36] The two members were Mohammed Hamdi Alulu and Yahya Abdul Qader Kurdo from Idlib, they were kidnapped from Qalamoun where surveillance camera footage from a bakery on the victims' route showed that motorcycles were chasing the car they were driving, minutes before contact with them was lost.

[38] On 7 March, The Syrian Popular Resistance stated that it had taken control of numerous villages in Jabal al Alawiyin and expanded the scope of its operations to Masyaf in the Hama countryside.