The Eparchy is not part of any ecclesiastical province, but is immediately subject to the Holy See and depends on the Dicastery for the Oriental Churches.

The first and current eparch of the Eparchy of Mississauga is Mar Jose Kalluvelil, who has been serving as its bishop since its creation in 2015.

As the immigrant population grew, there began a need for pastoral care.

The faithful attended Qurbana in various places such as churches, cafeterias, orgymnasiums.

The Cathedral was purchased in the 2010s; the Syro Malabars had previously been using a cafeteria as their gathering place.