A replacement station was opened in 1874 when the Midland Main Line was increased from two to four tracks.

[4] The station building, having been hidden by fencing for many years, was later dismantled and rebuilt at Midland Railway - Butterley with the help of David Wilson Homes, who erected a housing estate over the old station land in 2006.

Network Rail adopted a Route Utilisation Strategy for freight in 2007[5] which will create a new cross country freight route from Peterborough (East Coast Main Line) to Nuneaton (West Coast Main Line).

One of the next stages (around 2013) will create additional lines through Leicester during a re-signalling scheme, during this time Syston station will be rebuilt.

All services at Syston are operated by East Midlands Railway using Class 158 and 170 DMUs.