Until 1857, a railway line led through Szczecin from Berlin to Königsberg via Krzyż, Piła, Bydgoszcz, and Tczew.

Around 1900, the station building was constructed, and after renovations and reconstruction following the damages of World War II, it stands to this day.

In close proximity to the station, on Czarnieckiego Street, the headquarters of the West Pomeranian Regional Transport Company is located.

The complex of buildings housing the Railway Directorate in Szczecin dominates the area around the station.

In 2007 the station was partially renovated in connection with the end of the regatta The Tall Ships Races.

As part of this investment, the station building, platforms 1 and 4 were rebuilt and a new footbridge was built.

On 13 November 2018, PKP PLK signed an agreement with Railway Communication Works for the expansion of the passenger information system.