Tịnh Biên is a district-level town (thị xã) of An Giang province in the Mekong Delta region of Vietnam.

Tịnh Biên is about 125 km from Phnom Penh along National Highway 2 (CPC).

The Khmer population is relatively high, especially in the communes of An Cư, Tân Lợi, An Hảo, Giao Va and Vĩnh Trung.

A village in the district was depicted in Robin Moore's fiction book The Green Berets; chapter 1 described a real-life battle at Tịnh Biên during the Vietnam War in which all of the members of a United States Army Special Forces detachment were injured during the fighting.

[2] Due to its proximity to the border with Cambodia, tobacco and electronic goods are smuggled in Tịnh Biên.