In 1964, they signed with Atlantic Records and released their penned composition, "Who's That Lady", [disputed – discuss][1] which also failed to chart.

In the meantime, the success of "Shout" by other pop and rock acts had helped the song sell well over two million records in various versions.

This allowed the brothers, who owned the song as part of their Three Boys Music company, to move the family out of the Cincinnati suburb of Lincoln Heights into a house in Englewood, New Jersey.

After that record failed to chart, the brothers decided to have T-Neck distributed briefly by Atlantic Records, where the company released two more singles under the T-Neck name, featuring another Hendrix performance on the 1965 single, "Move Over and Let Me Dance", and the ballad "Wild as a Tiger", which did not include Hendrix.

Following these failures and an offer to record for Motown by its CEO, Berry Gordy, the brothers decided to temporarily fold T-Neck.

The brothers signed other acts such as Judy White and Baby Cortez during that time and had the singers recording their own music.

Most of the Isley Brothers' records were backed by a team of musicians ranging from different areas including legendary rhythm guitarist Charles "Skip" Pitts who, following the recording of Get Into Something (1970), left the Isleys to back Isaac Hayes' band where he created the memorable guitar riff for Hayes' signature hit, "Shaft".

Ernie Isley, who had joined his brothers' band as a drummer, played bass on a majority of their 1969-1970 recordings before switching over to electric guitar after he had been practicing the instrument for a while.

Seeking a bigger label to distribute their releases, CBS president Clive Davis signed the act to the Epic subsidiary in 1973.

This period of success continued into the late seventies with the releases of platinum-selling albums such as Harvest for the World (1976), Go for Your Guns (1977) and Showdown (1978).

By 1982, the T-Neck label was undergoing financial troubles no thanks in part due to the three elder Isleys' spending habits and failure to pay back taxes after a certain period.

Meanwhile, the decade-long 3+3 lineup was dealing with other issues including what later turned into a court battle against the two-halves of the act arguing over royalties and questionable songwriting credits (all of its CBS recordings were credited to all six members but were only issued on Triple Three Music and Three Boys Music giving the three older Isleys shares of the royalties).

Prior to this, the older Isleys managed to have most of Ernie's, Marvin's and Jasper's compositions recorded for Between the Sheets (1983).

By 1985, with severe financial problems, each of the brothers filed for Chapter 7 bankruptcy and T-Neck Records folded, giving up much of the label's assets to pay debts and to avoid imprisonment for tax evasion.