Powys was born in Shirley, Derbyshire, the son of the Reverend Charles Francis Powys (1843–1923), vicar of Montacute, Somerset, for 32 years, and Mary Cowper Johnson, grand-daughter of Dr John Johnson, cousin and close friend of the poet William Cowper.

Another brother, A. R. Powys, was secretary of the Society for the Protection of Ancient Buildings and published a number of books on architectural subjects.

[1] During the Spanish Civil War (1936–39), Powys was one of several UK writers who campaigned for aid to be sent to the Republican side.

[2] The novels Mr. Weston's Good Wine (1927) and Unclay (1931) and the short-story collection Fables are most praised, while his early non-fiction work The Soliloquy of a Hermit (1916) also has its admirers.

[1] Powys was deeply, if unconventionally, religious; the Bible was a major influence, and he had a special affinity with writers of the 17th and 18th centuries, including John Bunyan, Miguel de Cervantes, Jeremy Taylor, Jonathan Swift, and Henry Fielding.