His cousin, Ian Badder, was diagnosed with cystic fibrosis as a child and underwent a life-saving double-lung transplant in 2011.

In support, Brodie wore some stylish suits at the Catwalk for a Cure fashion show in July 2014 that raised more than $15,000 for Cystic Fibrosis Canada.

[5][6] Brodie was selected by the Saginaw Spirit in the third round of the Ontario Hockey League (OHL) priority selection in 2006, but opted out of the Cyclones program and spent the majority of the 2006–07 season with the Junior B Leamington Flyers, where he was voted the defensive rookie of the year and named to the rookie and first all-star teams in the Western Ontario Hockey League.

Seeking an offensive defenceman, the Calgary Flames selected Brodie in the fourth round, 114th overall, at the 2008 NHL Entry Draft.

[11] The Colts finished the year as the top-ranked team in the Canadian Hockey League (CHL), but were defeated by the Windsor Spitfires in the OHL championship series.

The team praised the improvements he made to his game, and anticipated that he would join their American Hockey League (AHL) affiliate, the Abbotsford Heat.

[16] TJ Brodie and New York Islanders player Josh Ho-Sang both have chosen to wear sweater #66, after Pittsburgh Penguins superstar Mario Lemieux, in a regular season game.

[24] He emerged as one of the Flames' top defencemen, averaging over 20 minutes of ice time per game and earning an invitation to join Team Canada at the 2013 IIHF World Championship.

[33] On October 9, 2020, after spending the first 10 years of his NHL career with the Calgary Flames, Brodie left the club as a free agent and was signed to a four-year, $20 million contract with the Toronto Maple Leafs.

[34] The Leafs also added other veteran presences to their lineup including Joe Thornton and Wayne Simmonds prior to the start of the shortened 2020–21 NHL season.

[39] At the conclusion of his four-year tenure with the Maple Leafs, Brodie left as a free agent and was signed to a two-year, $7.5 million contract with the Chicago Blackhawks on July 1, 2024.