Ramamoorthy was known as Mellisai Mannar (Tamil: மெல்லிசை மன்னர்; "The King of Light Music"), along with M. S. Viswanathan.

When he was fourteen, C. R. Subbaraman noted the young boy's talent and hired him as a violinist for HMV.

In the 1940s, Ramamoorthy worked in Saraswathi stores where AVM Studio's boss, Avichi Meiyappa Chettiar, was a partner in the shop.

T. K. Ramamoorthy, despite being an excellent musician with an orthodox Carnatic musical background, was a shy, modest and reserved person whereas M. S. Viswanathan was naturally talented, charming, forward and dynamic even if he lacked the similar background in Carnatic music.

[2] In addition, J. Jayalalithaa being the Chief Minister of Tamil Nadu, conferred the Thirai Isai Chakravarthy (Tamil: திரை இசை சக்ரவர்த்தி; "Emperors of the Cine Music") title in August 2012[3] and presented it to him, along with 60 gold coins and a new car.

[1] T.K.Ramamoorthy, in association with M.S.Viswanathan, composed music for over 100 films, starting with "Panam" in 1952 up till "Aayirathil Oruvan" in 1966, under the brand name 'Viswanathan–Ramamoorthy'.