Besides sporting events, the TD Garden has also served as a concert venue for numerous nationally touring acts in music and comedy.

The naming rights deal for the arena is scheduled to continue through June 2045, with TD Bank and Delaware North extending the agreement in January 2023.

Legislative leaders and Delaware North attempted to reach an agreement on plans for the new arena, but in February 1993 Bruins owner Jeremy Jacobs announced that he was backing out of the project as a result of the legislature's demand that his company pay $3.5 million in "linkage payments".

[15] Massachusetts governor Bill Weld lent strong support to a "Chapter 15" piece of legislation that included a "Section 7" that explicitly required Delaware North to "administer, produce, promote and sponsor no less than three charitable events per year at the New Boston Garden" and pay the proceeds from such events to the Metropolitan District Commission (MDC), today known as the state's Department of Conservation and Recreation.

[16] Two weeks later, after a new series of negotiations, the two sides finally came to an agreement, and on February 26 the legislature passed a bill that allowed for construction of a new sports arena.

Though the new arena was intended to be situated slightly north of the old facility, there were only nine inches (23 cm) of space between the two buildings when construction was completed.

Attendees included Bruins legends such as Bobby Orr and Phil Esposito as well as Celtics greats Larry Bird and Red Auerbach.

"[19] The following night, opening ceremonies were held at the FleetCenter, including performances by the Boston Pops, Walt Disney's World on Ice, Olympic figure skaters Nancy Kerrigan and Paul Wylie, and musical acts James Taylor, Patti LaBelle and US3.

On March 3, 2005, Maine-based TD Banknorth, a U.S. subsidiary of Toronto-Dominion Bank, announced its purchase of the naming rights for $6 million per year.

[9] In early 2005, while still searching for a long-term corporate sponsor, the FleetCenter conducted auctions on eBay to sell one-day naming rights.

Kerry Konrad, a New York City lawyer and Yankees fan, won naming rights for March 1 with a bid of $2,300.

He proposed the name "Derek Jeter Center" after the New York Yankees shortstop, a stab at fellow Harvard College alumnus and Boston Red Sox fan Jerry Rappaport Jr., with whom he had a 25-year-old rivalry.

An agreement was reached in which Rappaport added $6,300 for a total bid of $8,600, representing the 86 years of the Curse of the Bambino, and named the arena "New Boston Garden, Home of the Jimmy Fund Champions".

[30] Just before the 2018–19 series of pre-season NHL games began for the Bruins at TD Garden, the arena's interior overhead lighting was switched to a new LED system which also includes color elements at appropriate times.

TD Garden partnered with Clair Global Integration to add Cohesion Series CO10 loudspeakers to help improve the sound system.

[32] Among the non-sporting events hosted by the Garden are concerts, shows, graduations, seminars, Disney on Ice, the circus, and commencement exercises for Northeastern University.

It has hosted the following events: While dominant in their previous arena, Boston Garden, the Celtics and Bruins were initially much less successful in their new home as both teams missed the playoffs numerous times and failed to make their league's finals until 2008.

High school championships and tournaments for the Massachusetts Interscholastic Athletic Association are annually hosted at the TD Garden.

The Celtics are best known for the tradition of the parquet floor from their Boston Garden years, originally built after World War II because of cost and the scarcity of lumber in that time.

[36] For the 2024 NBA Cup, the court used was based on the team's "Statement" alternate uniform, this time incorporating a green gradient painted surface inspired by the iconic parquet floor.

When the 2012 NCAA Men's East Regional was held at TD Garden, a maple parquet floor was used with the same NCAA-specific design.

[39] In June 2024, the Celtics won their NBA-record 18th championship at TD Garden, beating the Dallas Mavericks and celebrating on the home floor.

[40] TD Garden hosted its first WNBA game on August 20, 2024, when the Connecticut Sun played the Los Angeles Sparks.

[42] Ricky Hatton began his "American dream" here on May 13, 2006, stepping up to welterweight to fight WBA world champion Luis Collazo.

[46][47] The TD Garden hosted UFC Fight Night: Shogun vs. Sonnen, the launch of the new Fox Sports 1 cable channel, on August 17, 2013.

Comedians such as Bill Burr, Denis Leary, Chris Rock and Louis C.K., among many others, have all performed at the TD Garden during their nationwide tours.

In addition, the arena has hosted several pay-per-views including WrestleMania XIV, Royal Rumble in 2003 and 2011, SummerSlam in 2006, Survivor Series in 2008, 2013 and 2022's Survivor Series: WarGames (Which introduced the WarGames match to WWE's main roster), Money in the Bank in 2014, TLC in 2015, Hell in a Cell in 2016, and Clash of Champions in 2017.

[55] In the spring of 2017, a group of local teenagers from the Hyde Square Task Force group investigated the terms of TD Garden's original development agreement, and concluded that its owners had never satisfied a legal requirement to host three fundraisers a year to benefit the agency that oversees Boston's recreational facilities.

[56] By mid-August 2017, the Massachusetts governor at the time of the TD Garden's original construction, Bill Weld, reminded Jeremy Jacobs about the deal he had made with the state's government in 1993 concerning the agreement.

[57] In May 2010, a bronze statue of Bruins defenseman Bobby Orr, in a flying pose celebrating "The Goal", was unveiled outside the stadium.