[5] TGF-α is synthesized internally as part of a 160 (human) or 159 (rat) amino acid transmembrane precursor.

Limited success has resulted from attempts to synthesize of a reductant molecule to TGF-α that displays a similar biological profile.

[8] Cell proliferation events that involve TGF-α bound to EGFR include wound healing and embryogenesis.

[10] A 170-kDa glycosylated protein known as the EGF receptor binds to TGF-α allowing the polypeptide to function in various signaling pathways.

[11] The EGF/TGF-α family has been shown to regulate luteinizing hormone-releasing hormone (LHRH) through a glial-neuronal interactive process.

This finding suggests a role for EGFR signaling in the regulation of CLOCK and circadian rhythms within the SCN.

[12] Similar studies have shown that when injected into the third ventricle TGF-α can suppress circadian locomotor behavior along with drinking or eating activities.

[16] This article incorporates text from the United States National Library of Medicine, which is in the public domain.